|
KMID : 0369319920120010046
|
|
Allergy
1992 Volume.12 No. 1 p.46 ~ p.55
|
|
|
Speific patterns of Bronchial Hyperresponsieness in Suspected Asthmatics
|
|
최인선
박재희/이신식/강유호/정익주/박경옥
|
|
|
Abstract
|
|
|
The presence of an increased airway responsiveness to histamine or to methacholine has been observed bot only in asthmatics but in patients with chronic obstructive pulmonary disease, cystic fibrosis, or other cardiopulmonary diseases. However,
it
was
suggested that some characteristic patternes of bronchial hyperresponsivenss(BHR) are specific for asthmatics. To evaluate the usefulness of methachoine broncial challenge as a specific diagnostic broncial challenge as a specific diagnostic test
of
asthma, the relationship between the degree of BHR and the pattern of dose-response curve were analyzed in 393 subjects with suspected asthma.
1. The slope of dose-response curve measured by modified Orehek´s method and the occurrence of "no plateau" determined by modified Woolcock´s method were related to the severity of BHR(p<0.001, respectively). And the relationship was continued
during
the improvement of bronchial responsiveness with antiasthma therapy in 20 patients with asthma.
2. There was a weak but significant relationship between BHR and the baseline lung function (r=0.24, p<0.01 in 163 positive patients; r=0.18, p<0.05 in 118 patients with positve methacholine and 70% or more predicted baseline FEV1).
3. Percent fall of FEV1 after challenge was related to BHR(X²=34.2 P<0.001).
These results suggest that the specific methacholine dose-response curve pattern and the characteristic saline responsiveness of asthma should be considered on the severity of BHR, and the characteristic severity of BHR on the baseline lung
function.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|